Glucose-regulated protein 78 (GRP78) autoantibodies are linked to blood–brain barrier dysfunction

Takeaway

  • Glucose-regulated protein 78 (GRP78) autoantibodies are associated with blood–brain barrier (BBB) dysfunction in paraneoplastic cerebellar degeneration (PCD) with Lambert-Eaton myasthenic syndrome (LEMS).

Why this matters

  • GRP78 antibodies may have applications in the development of BBB platforms that would facilitate the delivery of therapeutic antibodies to the brain.