Gadobutrol distribution patterns can be visualized after interstitial influx following focal blood-brain barrier (BBB) breakdown using non-invasive MR-guided focused ultrasound (MRgFUS) providing supporting evidence to the existence of the glymphatic system.
Why this matters
First characterized in rodents, the glymphatic system allows fluid exchange between brain interstitial and cerebrospinal fluid which could affect clearance of exogenously administered therapeutics as well as pathologic proteins.
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