Glymphatic efflux can be visualized after ultrasound-induced blood-brain barrier opening in humans

Takeaway

  • Gadobutrol distribution patterns can be visualized after interstitial influx following focal blood-brain barrier (BBB) breakdown using non-invasive MR-guided focused ultrasound (MRgFUS) providing supporting evidence to the existence of the glymphatic system.

Why this matters

  • First characterized in rodents, the glymphatic system allows fluid exchange between brain interstitial and cerebrospinal fluid which could affect clearance of exogenously administered therapeutics as well as pathologic proteins.

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