Group A streptococcus exposure and exacerbations of chronic tic disorders


  • Group A streptococcus (GAS) exposure is not a contributing factor for tic exacerbations in children with chronic tic disorders (CTD).

Why this matters

  • GAS has been extensively investigated in CTD, partly stemming from descriptions of pediatric acute neuropsychiatric syndromes (PANS) associated with GAS which comprise tics; however, studies exploring this phenomenon in mixed cohorts of children with either CTD or PANS have argued against this association.

  • The lack of association between GAS and CTD exacerbations adds to clinical knowledge of this condition, and provides a basis for further study examining immune activation by other pathogens that may be linked to tic severity, and their relationship with CTD clinical course.