Heterogeneous neuroimaging profiles of different pathologic causes of logopenic progressive aphasia


  • Postmortem imaging of people who had had logopenic progressive aphasia (LPA) revealed a variety of patterns of neurodegeneration associated with different pathologic causes including Alzheimer’s disease (AD) and diffuse Lewy body disease (DLBD).

Why this matters

    These findings highlight the clinical heterogeneity of the LPA phenotype and the potential role of biomarkers, with the authors noting choline esterase inhibitors as a potential treatment option and urging caution over the use of neuroepileptics (as these may cause behavioral dyscontrol in those with comorbid LPA-DLBD).