High body mass index and weight gain are associated with low risk of amyotrophic lateral sclerosis

Takeaway

  • In this population-based study, a high prediagnostic body mass index (BMI) was associated with low amyotrophic lateral sclerosis (ALS) risk.

  • The strength of this inverse relationship increased for up to 50 years after BMI measurement.

Why this matters

  • This population-based study showed that high BMI and weight gain are associated with a low risk of ALS. As the strength of this inverse relationship increased over time, this study demonstrates that long follow-up is necessary when assessing relationships between anthropometric measures and ALS risk.

  • This may be the first study reporting prediagnostic weight change measured both objectively and prospectively, minimizing measurement errors and eradicating recall bias.