In this population-based study, a high prediagnostic body mass index (BMI) was associated with low amyotrophic lateral sclerosis (ALS) risk.
The strength of this inverse relationship increased for up to 50 years after BMI measurement.
Why this matters
This population-based study showed that high BMI and weight gain are associated with a low risk of ALS. As the strength of this inverse relationship increased over time, this study demonstrates that long follow-up is necessary when assessing relationships between anthropometric measures and ALS risk.
This may be the first study reporting prediagnostic weight change measured both objectively and prospectively, minimizing measurement errors and eradicating recall bias.