Higher apolipoprotein E levels in lipoprotein subspecies linked to lower dementia risk

Takeaway

  • Higher apolipoprotein E levels in high-density lipoproteins lacking apolipoprotein C3 are associated with improved cognitive function and a lower risk of dementia.

Why this matters

    These findings suggest that previously identified cardioprotective associations of this novel apolipoprotein extend to dementia. Apolipoprotein E in high-density lipoproteins that lack apolipoprotein C3 could represent a novel target for therapeutic interventions.