Hippocampal abnormalities in temporal lobe epilepsy: it’s a family affair

Takeaway

  • People with temporal lobe epilepsy share morphological hippocampal abnormalities with their unaffected siblings.

Why this matters

    Hippocampal atrophy could represent a neuroimaging endophenotype of temporal lobe epilepsy, which precedes the symptomatic onset of epilepsy. This imaging feature could act as a potential biomarker for future genetic studies to identify common variants implicated in sporadic temporal lobe epilepsy.