Hippocampal subfield volume differs by phenotype in early-onset Alzheimer’s disease

Takeaway

  • Patients with amnestic early-onset Alzheimer’s disease (EOAD) have more extensive hippocampal volume loss than those with an atypical, visual-led EOAD phenotype, especially in the left CA1 and left hippocampal tail regions.

Why this matters

    Hippocampal atrophy is more widespread among patients with EOAD and symptomatic amnesia compared to those with EOAD and visual processing deficits, but the location and extent of hippocampal subfield involvement in each phenotype is unclear.