Distinct histopathological markers differently correlate with cortical atrophy in Alzheimer’s disease, highlighting their unique roles in the neurodegeneration process.
Why this matters
Alzheimer’s disease is characterized by cortical atrophy on magnetic resonance imaging and abnormal depositions of amyloid-beta, phosphorylated-tau, and inflammation pathologically but the relative contribution of these pathological hallmarks to cortical atrophy is unknown.
This unique study used a combined post-mortem in situ magnetic resonance imaging and histopathology approach to demonstrate that in Alzheimer’s disease, histopathological markers are important correlates of cortical atrophy, acquired both ante-mortem in vivo and post-mortem in situ. The findings further our understanding of the pathological mechanisms of magnetic resonance imaging atrophy patterns in Alzheimer’s disease.