Histopathological markers correlate distinctly with magnetic resonance imaging cortical atrophy in Alzheimer’s disease

Takeaway

  • Distinct histopathological markers differently correlate with cortical atrophy in Alzheimer’s disease, highlighting their unique roles in the neurodegeneration process.

Why this matters

  • Alzheimer’s disease is characterized by cortical atrophy on magnetic resonance imaging and abnormal depositions of amyloid-beta, phosphorylated-tau, and inflammation pathologically but the relative contribution of these pathological hallmarks to cortical atrophy is unknown.

  • This unique study used a combined post-mortem in situ magnetic resonance imaging and histopathology approach to demonstrate that in Alzheimer’s disease, histopathological markers are important correlates of cortical atrophy, acquired both ante-mortem in vivo and post-mortem in situ. The findings further our understanding of the pathological mechanisms of magnetic resonance imaging atrophy patterns in Alzheimer’s disease.