How common are seizures in people with familial cerebral cavernous malformations?


  • In children and adults with familial cerebral cavernous malformations (FCCM), seizures occurred in 42% of participants and was associated with more frequent hospital visits and hospitalizations.

Why this matters

  • Cerebral cavernous malformations (CCMs) are clusters of abnormally dilated capillaries in the brain, which commonly result in seizures and other neurological symptoms. FCCM is caused by autosomal dominant mutations in the CCM1, CCM2, or CCM3 genes.

  • Seizure incidence and severity has not been well described in cases of sporadic or familial CCM, particularly in children. This was the largest study of FCCM to date.