How does a transient ischemic attack affect health-related quality of life?


  • Prior to their attack, people with transient ischemic attack (TIA) had worsened health-related quality of life (HRQOL) compared to the population mean. However, there was no further worsening in HRQOL following TIA.

Why this matters

  • Patients with TIA experience a discrete attack of cerebral ischemia with complete resolution within 24 hours. However, following TIA, people have reported ongoing depression, fatigue, cognitive impairment, and reduced HRQOL. These ongoing effects are typically designated as psychological and physical outcomes of the TIA.

  • It has remained unclear, however, whether these ‘outcomes’ are a consequence of the attack or rather a reflection on the general reduced health quality of people who experience TIA.

  • To date, no studies have compared pre- and post-TIA measures of HRQOL in the same individuals, an investigation that would clarify the impact of TIA on HRQOL.