How is white matter integrity disrupted in the pre-clinical stages of Alzheimer’s disease ?

Takeaway

  • In people with subjective memory impairment (SMI), alterations in white matter (WM) integrity can be detected in the hippocampus before objective cognitive dysfunction.

Why this matters ?

  • SMI is indicative of an early stage of dementia, yet few studies have investigated WM alterations in individuals with this condition.