Hyposmia may predict conversion to neurodegenerative disease in idiopathic sleep behavior disorders

Takeaway

  • Hyposmia was the only clinical variable that significantly correlated with longitudinal change in dopamine transporter availability in people with idiopathic rapid eye movement sleep behavior disorder which could predict disease conversion to neurodegenerative diseases.

Why this matters

  • This is the first comprehensive positron emission tomography imaging study of dopamine transporter availability in people with idiopathic rapid eye movement sleep behavior disorder.

  • Hyposmia could be a novel clinical biomarker of neurodegeneration, with longitudinal change in dopamine transporter-patterns helping to predict conversion to neurodegenerative diseases.