Hypothalamus and deep limbic brain response to disgusting food images in Prader Willi syndrome


  • Neural response differs in the hypothalamus, amygdala, hippocampus, and periaqueductal gray (PAG) matter between patients with Prader Willi syndrome (PWS) and healthy controls when both are shown disgusting food images.

Why this matters

  • Altered control of appetite remains a common problem in PWS and insights into the origin of the brain response to food images may lead to better therapeutic interventions.