Identification and quantification of pain-related biomarkers in temporomandibular disorders


  • Quantification of biomarkers indicative of temporomandibular disorder (TMD) myalgia may help to provide greater understanding of the central and peripheral mechanisms that contribute to the development and maintenance of the disorder. 

Why this matters

  • TMD myalgia is characterized by spontaneous pain, intensified by function, hyperalgesia, and pain referral. The condition is associated with comorbidities such as depression, stress, and other psychological factors.

  • Evaluating the expression of indicative biomarkers of TMD myalgia in saliva and in plasma may help to elucidate their correlations with psychological distress.