Identification of disease activity biomarkers in primary progressive multiple sclerosis

Takeaway

  • A consistent interleukin 1 beta (IL1B) signature with selective upregulation of the NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome was present in people with primary progressive multiple sclerosis (PPMS), with higher IL1B gene expression levels associated with faster disease progression.

Why this matters

    Levels of IL1B gene expression in peripheral blood mononuclear cells may be a useful biomarker for identifying people with PPMS with a poorer prognosis who could benefit from therapies to delay disability progression.