Identification of new polymorphism associated with Parkinson’s Disease

Takeaway

  • Mutations in the promoter region of CD200R1 are associated with increased risk of Parkinson’s Disease (PD).

Why this matters ?

  • CD200R1, a membrane glycoprotein on microglia that is important to preventing microglial movement and thereby inflammation, is downregulated in patients with PD.

  • Single nucleotide polymorphisms (SNPs) in the promoter region of CD200R1 may be responsible for low expression in PD and act as risk factor for PD development.