Identification of target molecules in fluorescence-guided surgery for grade II/III glioma


  • Peptide transporter 2 (PEPT2) overexpression was associated with increased 5-aminolevulinic acid (ALA)-mediated fluorescence in World Health Organization (WHO) grade II/III gliomas, identifying it as a candidate molecule for the improvement of 5-ALA fluorescence-guided surgery (FGS).

Why this matters

  • Glioma is a common brain tumor and is difficult to treat; these results suggest PEPT2 is a potential candidate molecule that can be used to improve future surgical treatment.