Takeaway
Individuals positive for glycine receptor alpha 1 subunit (GlyRα1) antibodies present with clinical features characteristic of glutamic acid decarboxylase (GAD65) antibody syndrome, in addition to visual disturbances, parkinsonism and epilepsy.
Why this matters
Clinicians should consider testing individuals with low or negative GAD65 antibodies for GlyRα1-IgG, if they display phenotypes typical of GAD65 antibody syndromes, such as stiff-person syndrome.