Identifying two robust neuroanatomical biotypes of Parkinson’s disease


  • Two distinct neuroanatomical biotypes based on baseline imaging data were associated with specific clinical and prognostic features in patients with Parkinson’s disease (PD); these biotypes may help both in clinical prognosis and trial design.

Why this matters

  • PD is a heterogeneous disorder characterized by a range of motor and non-motor symptoms and varying disease course.

  • Identifying robust subcategories of patients with PD would allow for the stratification of clinical features, outcomes and underlying disease mechanisms, which could translate into an improved understanding of PD and more efficient clinical trials.

    • However, previous attempts to identify subcategories of PD patients have relied on symptom and demographic data and ultimately resulted in a range of controversial and heterogenous cluster-based findings with limited reproducibility.

  • Investigating potential subgroups from a baseline neuroanatomical focus may provide an accurate, reproducible and useful approach to stratifying patients with PD.