Imaging estimate of iron accumulation as a biomarker of small vessel disease progression

Takeaway

  • Cerebral iron accumulation was associated with increased permeability of the blood-brain barrier and decreased cognitive testing scores in people with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Why this matters

    These findings support investigation of the MRI imaging protocol estimating iron accumulation as a biomarker for disease progression in small vessel diseases such as CADASIL.