Imaging of high frequency oscillations for epileptogenic zone localization before resective surgery


  • Imaging of high frequency oscillation sources (HFOS) may provide a noninvasive alternative for epileptogenic zone localization (EZL) prior to resective surgery (RS) for medically refractory epilepsy (MRE).

Why this matters

  • Due to suboptimal EZL and RS, intractable seizures persist in approximately 20–50% of patients who undergo RS for MRE.

  • This study validates use of noninvasive imaging of sources of high frequency oscillations (HFO; 80–200 Hz) to delineate EZL using surgical outcomes (S-OUT) in patients who had RS for MRE.