Imaging study reveals local dynamic connectivity changes in subjective cognitive decline

New study findings have shed light on early changes in brain activity and connectivity during subjective cognitive decline (SCD).

In SCD – the preclinical stage of the Alzheimer’s disease (AD) spectrum – subjective cognitive complaints (SCCs) develop before objective cognitive impairment. Local disconnection, inefficient integration, and compensatory modifications are the signatures of early intrinsic brain activity (IBA) changes in the AD spectrum.

Dr Yi-Chia Wei from Chang Gung Memorial Hospital in Keelung, Taiwan, presented the results of a study using resting-state functional MRI (rs-fMRI) to evaluate dynamic IBA in SCD.