Immune profiles of patients with Alzheimer clinical syndrome

Takeaway

  • Understanding the mechanisms that influence adaptive immunity in patients with Alzheimer clinical syndrome (ACS) may facilitate the development of therapeutics to prevent or slow cognitive decline.

Why this matters

  • Alzheimer’s disease (AD), characterized by the accumulation of β-amyloid plaques and hyperphosphorylated tau tangles, remains the most common diagnosis of dementia and although diagnostic methods for AD have improved, effective therapies remain elusive.

  • Understanding the mechanisms behind AD development, such as the role of the innate and adaptive immune systems in neuroinflammation, may contribute to the development of effective therapeutics for AD.