Immunopathologic subtypes of multiple sclerosis are linked to clinical features and disease progression

Takeaway

  • Distinct immunopatterns are detected in active demyelinating lesions throughout the course of multiple sclerosis and are associated with clinical characteristics.

Why this matters

    Distinct pathological forms of acute multiple sclerosis plaques, known as immunopatterns, differ in the effector mechanism of demyelination, and the relationship between clinical outcomes and pathological immunopattern remains unclear. The findings of this novel study further our understanding of the clinical relevance of heterogeneous immunopatterns detected in early demyelinating lesions of people with multiple sclerosis. The variable outcomes after an acute attack suggests that early individualized treatment as either preventive or to aid recovery post-attack could help to prevent the onset of secondary progressive disease.