B cell-specific Moloney murine leukemia virus insertion site-1 (BMI1) is involved in cell metabolism of CD133-positive (CD133+) cells; integrin alpha 2 (ITGA2) is a pivotal downstream target of BMI1 and may be involved in the regulation of glioblastoma (GBM) stem cell properties.
Why this matters
GBM is the most aggressive adult brain cancer with low overall survival (median: 15 months), because of brain tumor initiating cells (BTICs) that are refractory to treatment.
BMI1 is an oncoprotein that impinges on many different signaling pathways involved in BTIC self-renewal and treatment resistance.
CD133+ neural stem cells (NSCs) have high levels of self-renewal and proliferation, which is enhanced by the presence of BMI1.
This work identifies three genes downstream of the CD133-BMI1 signaling pathway; these genes could be potential drug targets for treatment-resistant GBM cell populations.