Impact of IL6 receptor genotype on disease progression in people with amyotrophic lateral sclerosis

Takeaway

• The interleukin-6 receptor (IL6R)358 Ala variant is associated with an increased rate of disease progression in people with amyotrophic lateral sclerosis (ALS).

Why this matters

For the subgroup of patients who inherit the IL6R358 Ala variant (IL6R C allele), treatments that inhibit the IL6 receptor may be efficacious.