Impact of MRI-guided focused ultrasound thalamotomy in Parkinson’s disease on longitudinal neuronal activity


  • In treating Parkinson’s disease (PD) tremor, magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy leads to significant decreases in fractional amplitude of low-frequency fluctuations (fALFF) in the left occipital Brodman area 17 (BA17), which corresponds with tremor improvement.

Why this matters ?

  • MRgFUS is a minimally invasive procedure to reduce medication-refractory tremor in PD, but its effects on spontaneous neuronal activity have not been demonstrated.

  • Results from this study offer promise for the procedure, leading to improved morbidity outcomes in PD.