Impact of MRI-guided focused ultrasound thalamotomy in Parkinson’s disease on longitudinal neuronal activity


  • In treating Parkinson’s disease (PD) tremor, magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy leads to significant decreases in fractional amplitude of low-frequency fluctuations (fALFF) in the left occipital Brodman area 17 (BA17), which corresponds with tremor improvement.

Why this matters

    MRgFUS is a minimally invasive procedure to reduce medication-refractory tremor in PD, but its effects on spontaneous neuronal activity have not been demonstrated. Results from this study offer promise for the procedure, leading to improved morbidity outcomes in PD.