Impact of subthalamic nucleus stimulation on focal motor seizures


  • High-frequency stimulation of the subthalamic nucleus (STN) can reduce interictal spikes (IIS) and high-frequency oscillations (HFO) on the motor cortex in people with focal motor epileptic seizures.

Why this matters

  • Surgical resection is a therapeutic option for people with drug-resistant focal motor epileptic seizures, but this is associated with neurological deficits.

  • Deep brain stimulation of the STN might represent an alternative to surgical resection that alleviates seizures while preserving neurological function.