In Lewy body diseases, ß-amyloid deposition exacerbates cognitive decline over a 1-year period

Takeaway

  • Amyloidosis plays a key role in neurodegenerative progression in Lewy body diseases and impairs global cognition, attentive/executive, and semantic recall function.

Why this matters

    Dementia in Lewy body diseases significantly impairs physical and mental well-being and there is a need to determine its pathogenesis to allow for better targeted pharmacotherapeutics. This unique study combined positron emission tomography and magnetic resonance imaging techniques to investigate the contribution of synuclein- and amyloid-pathology in exacerbating cognitive decline; the findings could help to inform disease-modifying strategies.