In vivo imaging and post-mortem pathology of primary 4-repeat tauopathies

Takeaway

  • In progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), postmortem neurodegeneration and tau inclusion burden correlated significantly with brain atrophy measured during life via magnetic resonance imaging (MRI).

Why this matters

  • The autopsy-confirmed correlation indicates that in vivo measures of regional brain atrophy may be adequate biomarkers of tau burden in primary tauopathies.