Increased blood purine concentrations as a biomarker of epilepsy and seizures

Takeaway

  • Blood purine concentrations are increased during experimental seizures and human epilepsy compared with appropriate controls and correlate with neurodegeneration and seizure burden.

Why this matters

    The current gold-standard method to diagnose epilepsy involves time-consuming and costly video-electroencephalographic (EEG) recording and guidance from specialists. With relatively new technology that allows for the identification of adenosine in blood, measurements of blood purine may offer a rapid and cost-effective way to aid in epilepsy diagnoses.