Increased risk of incident mild cognitive impairment in APOE ε4 allele carriers and those with higher medical burden


  • In a large ethnically diverse cohort, almost 50% of individuals with incident mild cognitive impairment diagnoses are wrongly classified as cognitively normal at follow-up.

Why this matters

  • Identifying risk factors for mild cognitive impairment in cognitively normal older adults could help to characterize a target group for dementia interventional strategies; however, this is hindered by the lack of data on predictors of progression in an ethnically diverse population.

  • This important study extends previous reports on predictors of progression in prevalent mild cognitive impairment in a multi-ethnic community-based cohort by identifying modifiable and non-modifiable risk factors of progression.