Increased worsening of patients with amyotrophic lateral sclerosis during COVID-19 lockdown


  • Increased rate of amyotrophic lateral sclerosis (ALS) worsening was observed during COVID‑19 lockdown in France.

Why this matters

  • ALS is the most frequent motor neuron disorder in adults and leads to poor survival outcomes (death in a median time of 3 years after onset).

  • In patients with ALS, follow-up in tertiary centers improve quality of life and survival; such in-person follow-up was limited or stopped during the COVID-19 pandemic and the subsequent country lockdowns.

  • Physicians and health authorities should be aware of the possible increased risk of ALS worsening in patients during future sanitary restrictions.