Increased rate of amyotrophic lateral sclerosis (ALS) worsening was observed during COVID‑19 lockdown in France.
Why this matters
ALS is the most frequent motor neuron disorder in adults and leads to poor survival outcomes (death in a median time of 3 years after onset).
In patients with ALS, follow-up in tertiary centers improve quality of life and survival; such in-person follow-up was limited or stopped during the COVID-19 pandemic and the subsequent country lockdowns.
Physicians and health authorities should be aware of the possible increased risk of ALS worsening in patients during future sanitary restrictions.