Induction of mitophagy reduces Alzheimer’s disease symptoms and pathology in animal models

Takeaway

  • Reduced mitophagy was observed in brain tissue of those with Alzheimer’s disease (AD), and pharmacological induction of mitophagy in animal models of AD improved memory, reduced amyloid-β levels and decreased hyperphosphorylation of tau.

Why this matters

  • Maintaining neuronal mitochondrial quality is a promising therapeutic approach for treating Alzheimer’s disease.