Inflammatory and senescent microglia in fragile X-associated tremor/ataxia syndrome

Takeaway

  • Activated and dying microglial cells contribute to the worsening of fragile X-associated tremor/ataxia syndrome (FXTAS) pathology and functional decline.

Why this matters

  • Senescent microglial cells can be a potential biomarker for post-mortem diagnosis and anti-inflammatory regimens may slow neurodegenerative deterioration in patients with FXTAS.