Inflammatory phenotype of human microglial-like cells derived from Alzheimer’s disease patients

Takeaway

  • The study describes the development of a method to derive human microglial-like cells (iMGLs) from induced pluripotent stem cells (iPSCs) and the inflammatory phenotype of iMGLs from Alzheimer’s disease (AD) patients.

Why this matters

    Human microglial cells are important in AD pathogenesis but difficult to obtain; development of a technique to derive these cells will provide a valuable tool for AD research.