Influence of abnormal effector and regulatory T cell subsets in pediatric-onset multiple sclerosis

Takeaway

  • Abnormalities in the frequencies and functional responses of pro-inflammatory CD4 and CD8 T cells in pediatric-onset multiple sclerosis (MS) compared to healthy controls and other central nervous system (CNS) inflammatory disease were identified.

Why this matters

  • Focusing on both the effector (Teff) and regulatory T cells (Treg) in MS may allow more selective targeting for treatment. Studies in pediatric-onset MS also allows examination of early disease mechanisms.