Inner retinal layer thinning predicts conversion to multiple sclerosis


  • As the thinning of the peripapillary retinal nerve fiber layer (pRNFL) and the common ganglion cell and inner plexiform layer (GCIP) is an independent risk factor for conversion to multiple sclerosis (MS) in people with radiologically isolated syndrome (RIS), retinal optical coherence tomography (OCT) could be a useful tool for risk stratification in these individuals.

Why this matters

  • About one third of people with RIS convert to MS within five years, therefore RIS can be considered a preclinical form of MS and a potential prognostic marker to assist in clinical decision-making and identify patients who might benefit from early immunomodulatory treatment.

  • This study identified the inner retinal layer thinning as an independent risk factor for conversion to MS in people with RIS.