Intensive versus standard blood pressure control for cognitive decline and dementia


  • Aggressive blood pressure (BP) control is not associated with lower risk in cognitive decline, dementia, or mild cognitive impairment (MCI) compared to standard BP treatment.

Why this matters

  • Cerebrovascular disease (CVD) is a major risk factor for the development of neurodegenerative conditions, such as dementia, with high BP being an important risk factor for CVD.

  • In 2019, the World Health Organization guidelines recommended that adults with hypertension should receive standard hypertension management to reduce the risk of cognitive decline and/or dementia.

  • It is uncertain whether lower BP targets can yield better benefit cognitive outcomes than standard BP treatment.