Interferon gene signatures in myositis

Takeaway

  • Type 1 interferon (IFN1) and type 2 interferon (IFN2) pathways are differentially activated in different forms of myositis.

Why this matters

    Activation of IFN1 and IFN2 pathways in different types of myositis are incompletely understood; may have therapeutic implications because immunosuppressive medications may preferentially target each pathway.