Interictal epileptiform discharges modulate neuron activity involved in memory formation


  • Interictal epileptiform discharges (IEDs) in the hippocampus have been observed to modulate neurons that are involved in memory formation and recall.

Why this matters

  • It is not well understood why patients with memory deficits are often seen with IEDs on interictal electroencephalography.

  • These IEDs have been previously associated with transient cognitive impairments.

  • Developing the understanding of how IEDs affect individual neurons is important for developing our knowledge of memory impairments in epilepsy patients.