Interleukin-6 is a marker of futile reperfusion following mechanical thrombectomy


  • Interleukin-6 (IL-6) is a marker of futile reperfusion in patients with acute ischemic stroke (AIS) and large vessel occlusion (LVO) treated with mechanical thrombectomy (MT).

Why this matters

  • IL-6 levels were previously observed to be associated with stroke severity and outcome, but its prognostic and predictive value in clinical practice remains unclear.

  • The rate of futile reperfusion after MT for AIS with LVO was reported to be ~54%, attributed to both thrombotic and inflammatory pathways; the role of IL-6 has not been studied.

  • This study provides evidence of IL-6 as a factor that influences outcomes after reperfusion, and potentially helps in clinical decision-making.