The internuclear ophthalmoplegia-medial longitudinal fasciculus model is a suitable tool for investigating the clinico-radiological paradox in multiple sclerosis.
Why this matters
The clinico-radiological paradox in multiple sclerosis is defined as a mismatch between visible lesions on imaging scans and clinical disability. Better understanding of this paradox would enable more sensitive and specific surrogates of relapses and disability progression. This is the first blinded study to investigate medial longitudinal fasciculus lesions in an unselected group of multiple sclerosis individuals. The findings suggest that internuclear ophthalmoplegia detection with infrared oculography is a sensitive functional outcome measure that is clinically relevant and could help inform treatment choices.