Interplay between early Alzheimer’s disease-related pathology, brain networks and cognition

Takeaway

  • In deceased adults, low levels of Alzheimer’s disease-related pathologic change are linked to region-specific changes in brain network organization.

Why this matters

    Changes in network topology in specific brain regions could act as early biological markers for microstructural changes related to β-amyloid pathology. This could enable identification of individuals at risk for developing Alzheimer’s disease.