Intra-cortical myelination in sleep quality and emotional reactivity


  • Intra-cortical myelin in the anterior orbitofrontal cortex (OFC) mediated the negative impact of poor sleep on affective behavior.

Why this matters

  • Poor sleep is commonly associated with cognitive and emotional deficits, and recent animal studies show detrimental effects on brain myelination due to sleep deprivation; however, an association between these deficits has not been ascertained.

  • Greater understanding of the impact of poor sleep on the brain is vital for sleep disorder treatment and health awareness campaigns, particularly given that poor sleep has become the norm for most modern societies.