Intratumor heterogeneity in glioblastoma-derived cell lines

Takeaway

  • Intratumoral heterogeneity (ITH) in glioblastoma (GBM) affects radiosensitivity and may impact treatment response.

Why this matters

  • GBMs have been shown to display ITH consistent with a high degree of clonal diversity.

  • The significant difference in radiosensitivity in two cell lines derived from the same tumor suggests ITH may affect radiosensitivity in a tumor-dependent manner.