Investigating epidermal innervation density in people with Rett syndrome

Takeaway

  • Investigations of epidermal innervation in people diagnosed with Rett syndrome (RTT) reveal increased epidermal nerve fiber (ENF) peptidergic (co‐stained calcitonin gene‐related protein [CGRP]) innervation density compared with healthy females, suggesting that hyperinnervation may be the result of proliferation of peptidergic fibers.

Why this matters

  • In the absence of previous direct investigations of epidermal sensory innervation in people with RTT, these preliminary observations of ENF peptidergic fiber density differences provides important information on the peripheral neurobiology in RTT.