Investigating mixed pathologies in mouse models of tauopathy and synucleinopathy

Takeaway

  • Human recombinant tau and human recombinant α-synuclein fibrillar species can cross-seed efficiently in mouse models of tauopathy and synucleinopathy and copolymers of tau and α-synuclein fibrils were efficient in potentiating central nervous system (CNS) transmission of induced tau pathology but not synucleinopathy.

Why this matters

  • In patients with Alzheimer’s disease (AD), the presence of mixed pathologies of tau and α-synuclein is associated with a higher risk of dementia. Previous research shows that these mixed pathologies present as co-aggregates, suggesting that this pathological effect may occur as a result of interaction between these proteins.

  • Investigating how cross-seeding of tau and α-synuclein can influence proteinopathy can help to aid the understanding of the etiology of mixed pathologies in AD type dementias.