Investigating sympathetic cardiac denervation in Alzheimer’s disease with Lewy bodies

Takeaway

  • Sympathetic cardiac denervation might be driven by alpha-synuclein pathology, suggesting that in vivo testing for sympathetic cardiac denervation could allow clinical differentiation between Alzheimer’s disease (AD) and Alzheimer’s disease with comorbid dementia and Lewy bodies (AD/DLB).

Why this matters ?

  • Comorbid Lewy body pathology is very common in AD, yet there is currently no in vivo test to identify this. Developing a test that can differentiate living patients with AD from patients with AD/DLB would aid physicians in providing more effective treatment.

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